Aurora Kinase Inhibitors

Aurora Kinase

Aurora A

Aurora B

Aurora C

Aurora Kinase Inhibitors, Degraders & Ligands

Product Name	Aurora Kinase	Aurora A	Aurora B	Aurora C	Purity
Alisertib		Aurora A, IC₅₀: 1.2 nM	Aurora B, IC₅₀: 396.5 nM		99.84%
Barasertib			Aurora B, IC₅₀: 0.37 nM		99.50%
Barasertib-HQPA			Aurora B, IC₅₀: 0.37 nM		98.90%
Tozasertib		Aurora A, Ki: 0.6 nM	Aurora B, Ki: 18 nM	Aurora C, Ki: 4.6 nM	99.92%
Reversine		Aurora A, IC₅₀: 400 nM	Aurora B, IC₅₀: 500 nM	Aurora C, IC₅₀: 400 nM	99.22%
CCT400028		Aurora A, Kd: 71 nM	Aurora B, Kd: 2100 nM	Aurora C, Kd: >10 μM	98.03%
PROTAC AURKA degrader 2		Aurora A, IC₅₀: 3.58 nM	Aurora B, IC₅₀: 77.2 nM		98.36%
Aurora kinase/HDAC-IN-1		Aurora A, IC₅₀: 116 nM	Aurora B, IC₅₀: 225 nM
JNJ-7706621		Aurora A, IC₅₀: 11 nM	Aurora B, IC₅₀: 15 nM		99.39%
Hesperadin			Aurora B, IC₅₀: 250 nM		98.89%
ZM-447439		Aurora A, IC₅₀: 110 nM	Aurora B, IC₅₀: 130 nM		99.19%
KW-2449		Aurora A, IC₅₀: 48 nM			99.91%
AT9283		Aurora A, IC₅₀: 3 nM	Aurora B, IC₅₀: 3 nM		99.67%
Danusertib		Aurora A, IC₅₀: 13 nM	Aurora B, IC₅₀: 79 nM	Aurora C, IC₅₀: 61 nM	99.08%
LY3295668		Aurora A, Ki: 0.8 nM	Aurora B, Ki: 1038 nM		99.76%
AMG 900		Aurora A, IC₅₀: 5 nM	Aurora B, IC₅₀: 4 nM	Aurora C, IC₅₀: 1 nM	98.82%
MK-5108		Aurora A, IC₅₀: 64 pM			99.60%
GRK6-IN-1		Aurora A, IC₅₀: 8.9 μM			99.61%
GSK-1070916			Aurora B, Ki: 0.38 nM	Aurora C, Ki: 1.5 nM	99.55%
PF 477736		Aurora-A, IC₅₀: 23 nM			99.04%
MLN8054		Aurora A, IC₅₀: 4 nM			99.01%
TAK-632			Aurora B, IC₅₀: 66 nM		98.93%
PF-03814735		Aurora 1, IC₅₀: 0.8 nM	Aurora 2, IC₅₀: 5 nM		99.45%
GRK2 Inhibitor 2		Aurora A, IC₅₀: 137 nM			99.92%
5-Bromothiazol-2-amine		Aurora A			99.96%
Tinengotinib		Aurora A	Aurora B		99.57%
JB170		Aurora A, DC₅₀: 28 nM Aurora A, Kd: 99 nM Aurora A, EC₅₀: 193 nM			98.70%
ENMD-2076		Aurora A, IC₅₀: 14 nM			99.99%
CD532		Aurora A, IC₅₀: 45 nM			98.86%
SNS-314 mesylate		Aurora A, IC₅₀: 9 nM	Aurora B, IC₅₀: 31 nM	Aurora C, IC₅₀: 6 nM	99.53%
TAK-901		Aurora A, IC₅₀: 21 nM	Aurora B, IC₅₀: 15 nM		99.84%
GRK6/Aurora A-IN-1		Aurora A, IC₅₀: 11 nM			98.98%
Cenisertib		Aurora-A	Aurora-B		99.86%
CCT 137690		Aurora A, IC₅₀: 15 nM	Aurora B, IC₅₀: 25 nM	Aurora C, IC₅₀: 19 nM	99.54%
GW779439X		Aurora A			99.85%
CAM2602		Aurora A, Kd: 19 nM			99.85%
TCS7010		Aurora A, IC₅₀: 3.4 nM	Aurora B, IC₅₀: 3.4 μM		99.82%
JAB-2485		Aurora A, IC₅₀: 0.327 nM			99.87%
ML281			Aurora B		98.04%
dAurAB5		Aurora-A, DC₅₀: 8.8 nM	Aurora-B, DC₅₀: 6.1 nM		99.03%
SK2188		Aurora A			99.87%
CYC-116		Aurora A, Ki: 8 nM	Aurora B, Ki: 9.2 nM		99.05%
TAS-119		Aurora A, IC₅₀: 1 nM	Aurora B, IC₅₀: 95 nM		98.01%
Ilorasertib		Aurora A, IC₅₀: 120 nM	Aurora B, IC₅₀: 7 nM Aurora B (Y156H), IC₅₀: 12 nM	Aurora C, IC₅₀: 1 nM	99.86%
BI-847325				Aurora C, IC₅₀: 15 nM	98.15%
Chiauranib			Aurora B, IC₅₀: 9 nM		98.97%
MK-8745		Aurora A, IC₅₀: 0.6 nM			99.08%
SP-96		Aurora A, IC₅₀: 18.975 nM	Aurora B, IC₅₀: 0.316 nM		99.65%
CCT129202		Aurora A, IC₅₀: 42 nM	Aurora B, IC₅₀: 198 nM	Aurora C, IC₅₀: 227 nM	99.62%
PHA-680632		Aurora A, IC₅₀: 27 nM	Aurora B, IC₅₀: 135 nM	Aurora C, IC₅₀: 120 nM	98.07%
Ilorasertib hydrochloride		Aurora A, IC₅₀: 120 nM	Aurora B, IC₅₀: 7 nM Aurora B (Y156H), IC₅₀: 12 nM	Aurora C, IC₅₀: 1 nM	98.48%
XL228		Aurora A, IC₅₀: 3.1 nM			99.64%
NU6140		Aurora A, IC₅₀: 67 nM	Aurora B, IC₅₀: 35 nM		99.53%
dAURK-4 hydrochloride		Aurora A			98.14%
SCH-1473759		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM		98.51%
SCH-1473759 hydrochloride		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM		99.19%
Aurora kinase inhibitor-3		Aurora A, IC₅₀: 42 nM			99.05%
Aurora kinase inhibitor-2		Aurora A, IC₅₀: 310 nM	Aurora B, IC₅₀: 240 nM		99.08%
ENMD-2076 Tartrate		Aurora A, IC₅₀: 1.86 nM			99.66%
CCT241736		Aurora-A, IC₅₀: 38 nM Aurora-A, Kd: 7.5 nM	Aurora-B, Kd: 48 nM		99.88%
PROTAC MPS1 degrader 1		Aurora A, DC₅₀: 108.7 nM	Aurora B, DC₅₀: 570.3 nM		99.90%
AurAP14		Aurora A, DC₅₀: 120 nM			99.33%
DB0614	Aurora Kinase
GSK2646264		Aurora A, pIC₅₀: <4.3	Aurora B, pIC₅₀: <4.6		98.39%
TC-A 2317 hydrochloride		Aurora A, Ki: 1.2 nM	Aurora B, Ki: 101 nM		99.57%
Glycyl H-1152 hydrochloride		Aurora A, IC₅₀: 2.35 μM			99.9%
AKI603		Aurora A, IC₅₀: 12.3 nM			98.03%
Aurora-A ligand 1		Aurora A			98.75%
MS44			Aurora B, DC₅₀: 103 nM
Aurora kinase-IN-8		Aurora A, IC₅₀: 2.8 nM	Aurora B, IC₅₀: 28.1 nM
Phthalazinone pyrazole		Aurora-A, IC₅₀: 0.031 μM			98.0%
Alisertib sodium		Aurora A, IC₅₀: 12.5 nM	Aurora B, IC₅₀: 396.5 nM
AT9283 lactic acid		Aurora A, IC₅₀: 3 nM	Aurora B, IC₅₀: 3 nM
Hesperadin hydrochloride			Aurora B, IC₅₀: 250 nM
Aurora inhibitor 1		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM
Aurora kinase inhibitor-13		Aurora A, IC₅₀: 2.3 μM
Aurora A-IN-5		Aurora A, IC₅₀: 0.02 μM
HLDA-212		Aurora A	Aurora B
Aurora kinase-IN-10		Aurora A, IC₅₀: 5.94 nM	Aurora B, IC₅₀: 86.06 nM
SK5527		Aurora A, DC₅₀: 2 nM
LCI133		Aurora A, IC₅₀: 2.8 nM	Aurora B, IC₅₀: 10.6 nM
dAURK-4		Aurora A
FAK-IN-22			Aurora B, IC₅₀: 0.49 nM
Aurora kinase inhibitor-14		Aurora A, IC₅₀: 0.5 nM	Aurora B, IC₅₀: 1.2 nM
Aurora A inhibitor 2		Aurora A, IC₅₀: 21.94 nM	Aurora B, IC₅₀: 273.18 nM
PROTAC AURKA degrader 1		Aurora A
CG-1521			Aurora B
SK4454		Aurora A, IC₅₀: 20 nM Aurora A, Ki: 1 nM	Aurora B, Ki: 7644 nM
IBPR002		Aurora A, IC₅₀: 41 nM	Aurora B, IC₅₀: 17 nM
Aurora kinase/ALK-IN-1		Aurora A, IC₅₀: 0.296 μM	Aurora B, IC₅₀: 0.887 μM
(Rac)-Aurora A/PKC-IN-1		Aurora A, IC₅₀: 6.9 nM
CDK2-IN-55		Aurora A, IC₅₀: 92 nM			98.91%
RET-IN-19		Aurora A, IC₅₀: 0.242 ± 0. μM	Aurora B, IC₅₀: 0.536 ± 45 μM
SNS-314		Aurora A, IC₅₀: 9 nM	Aurora B, IC₅₀: 31 nM	Aurora C, IC₅₀: 6 nM
Aurora kinase inhibitor-10			Aurora B, IC₅₀: 8 nM
Aurora A/PKC-IN-1		Aurora A, IC₅₀: 6.9 nM
Aurora-A ligand 2		Aurora A
XMD-12		Aurora A, IC₅₀: 5.6 nM	Aurora B, IC₅₀: 18.4 nM	Aurora C, IC₅₀: 24.6 nM	99.32%
AurkA allosteric-IN-1		Aurora A, IC₅₀: 6.5 μM (^[1])
Butrin			Aurora B
Aurora kinase-IN-2		Aurora A, IC₅₀: 90 nM	Aurora B, IC₅₀: 152 nM
Aurora kinase inhibitor-9		Aurora A, IC₅₀: 0.093 μM	Aurora B, IC₅₀: 0.09 μM
CDK1-IN-9		Aurora A, IC₅₀: 77.8 nM
BRD-7880		Aurora A, IC₅₀: 2153 nM	Aurora B, IC₅₀: 7 nM	Aurora C, IC₅₀: 12 nM
LS-Q2		Aurora A, IC₅₀: 212 nM
AURKA-IN-3		Aurora A, IC₅₀: 23.0 nM
LY3295668 erbumine		Aurora A, Ki: 0.8 nM	Aurora B, Ki: 1038 nM
MK-5108-NH-PEG2-alkyne		Aurora A
SAR156497		Aurora A, IC₅₀: 0.6 nM	Aurora B, IC₅₀: 1 nM
TAK-901 hydrochloride		Aurora A, IC₅₀: 21 nM	Aurora B, IC₅₀: 15 nM
PROTAC Aurora A Degrader-1		Aurora A
Benzo[c][1,8]naphthyridin-6(5H)-one		Aurora A, IC₅₀: 5.5 μM
TY-011		Aurora A	Aurora B
Binucleine 2			Aurora B
Aurora A inhibitor 4		Aurora A
Aurora B inhibitor 1			Aurora B, Ki: 0.01 μM

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